Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 128, Issue 6, Pages 434-447Publisher
WILEY
DOI: 10.1111/acps.12143
Keywords
early-life stress; childhood abuse; neurobiology; treatment
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Funding
- National Institute of Mental Health [R01 MH083704, R21 MH091508, R01 MH068767-01]
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ObjectiveThis article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications. MethodFindings from a broad array of human and animal studies of early adversity were reviewed. ResultsTopics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed. ConclusionEarly adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.
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