Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 126, Issue 6, Pages 402-410Publisher
WILEY
DOI: 10.1111/j.1600-0447.2012.01892.x
Keywords
C-reactive protein/analysis; mental health; health status; stress; psychological/immunity; health surveys
Categories
Funding
- NIH [5R01MH068767-08]
- National Institutes of Mental Health
- NARSAD
- UCB Pharma
- Sepracor
- Cyberonics
- Department of Defense
- Medtronic
- Neuronetics
- NeoSync
- National Institute of General Medical Sciences [R25 GM083270]
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Objective: To determine whether C-reactive protein (CRP) can serve as a marker for alterations in immune function prior to the manifestation of significant psychiatric and medical disorders. Method: Ninety-two healthy adults were recruited from the community and determined to be free of psychiatric or medical disorders. The concentration of plasma CRP from a single resting sample was examined in relation to current mental and physical health as well as to self-reported history of early life adversity. Results: C-reactive protein showed a significant positive correlation with body mass index (BMI; r = 0.477, P < 0.001). Non-specific pain, fatigue, and lower overall quality of physical health were all associated with higher CRP concentrations (all P < 0.05 or P < 0.01), after controlling for effect of BMI and other relevant covariates. Subthreshold depression symptoms and other indices of mental/emotional wellbeing were not associated with CRP, nor was CRP significantly linked to any measures of early life adversity. Conclusion: Lower-quality physical health and wellbeing, but not the presence of mood/anxiety symptoms or early life stress (ELS), were significantly related to plasma CRP. Elevated CRP does not appear to be a fundamental consequence of ELS among healthy adults.
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