Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 125, Issue 3, Pages 194-202Publisher
WILEY
DOI: 10.1111/j.1600-0447.2011.01764.x
Keywords
anxiety traits; Harm Avoidance; Neuroticism; SLC6A4 gene; brain-derived neurotrophic factor gene; GABRA6 gene
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Funding
- Ministerio de Educacion y Ciencia [SAF 2005-07852-C02-01]
- Ministerio de Ciencia e Innovacion [SAF2008-05674-C03-01, PSI2008-05988]
- Ministerio de Sanidad y Consumo [05-317]
- Fondos FEDER
- Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya [2009SGR827]
- Spanish Ministry of Health
- CIBERSAM
- Institut de Biomedicina de la Universitat de Barcelona (IBUB)
- Departament d'Universitats, Recerca i Societat de la Informacio (DURSI) de la Generalitat de Catalunya [2004 FI 00673]
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Objective: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brainderived neurotrophic factor gene (BDNF) and the GABA(A)alpha(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample. Method: A sample of 937 individuals from the general population completed the Temperament and Character Inventory questionnaire to explore Harm Avoidance (HA) dimension; a subsample of 553 individuals also filled in the Big Five Questionnaire to explore the Neuroticism dimension. The whole sample was genotyped for the 5-HTTLPR polymorphism (SLC6A4 gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). Results: Homozygous individuals for the T allele of the T1512C polymorphism presented slightly higher scores for HA than C allele carriers (F = 2.96, P = 0.019). In addition, there was a significant gene-gene interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F = 3.4, P = 0.009). Conclusion: GABRA6 emerges as a candidate gene involved in the variability of HA. The effect of a significant gene-gene interaction between the SLC6A4 and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.
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