Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 122, Issue 6, Pages 481-487Publisher
WILEY
DOI: 10.1111/j.1600-0447.2010.01582.x
Keywords
neuroimaging; psychopharmacology; affective disorders
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Funding
- Astra-Zeneca
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Objective: To investigate the effect of lithium, anticonvulsants and antipsychotics on brain structure in bipolar disorder (BD). Method: A cross-sectional structural brain magnetic resonance imaging study of 74 remitted patients with BD, aged 18-65, who were receiving long-term prophylactic treatment with lithium or anticonvulsants or antipsychotics. Global and regional grey matter, white matter, and cerebrospinal fluid volumes were compared between treatment groups. Results: Grey matter in the subgenual anterior cingulate gyrus on the right (extending into the hypothalamus) and in the postcentral gyrus, the hippocampus/amygdale complex and the insula on the left was greater in BD patients on lithium treatment compared to all other treatment groups. Conclusion: Lithium treatment in BD has a significant effect on brain structure particularly in limbic/paralimbic regions associated with emotional processing.
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