Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 119, Issue 3, Pages 199-208Publisher
WILEY
DOI: 10.1111/j.1600-0447.2008.01297.x
Keywords
schizophrenia; theory of mind; voxel-based morphometry; frontal lobe; temporal lobe
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Funding
- Foundation for Psychiatry and Psychotherapy Research
- Hungarian Neuroimaging Foundation
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We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.
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