Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 120, Issue 3, Pages 196-202Publisher
WILEY
DOI: 10.1111/j.1600-0447.2009.01359.x
Keywords
cortisol; saliva; major depression; light therapy; prediction
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Funding
- Danish Medical Research Council
- Eastern Region Research Foundation
- Merchant L.F. Foght's Foundation
- Johannes M. Klein and Wife's Memorial foundation
- The Tvergaard Foundation
- The Danish Psychiatric Association
- Olga Bryde Nielsen's Foundation
- The A.P. Mcircle divideller and Chastine Mc-Kinney Mcircle divideller Foundation
- The Region 3 Foundation
- The Frederiksborg General Hospital Research Fund
- Pfizer, Copenhagen, Denmark
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Objective: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. Method: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. Results: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. Conclusion: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.
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