Journal
ACTA PHYSIOLOGICA
Volume 204, Issue 2, Pages 255-266Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1748-1716.2011.02338.x
Keywords
cannabinoids; endocannabinoids; intestine; receptor; TRP channels
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Funding
- GW Pharmaceuticals Ltd., UK
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Aim: Plant cannabinoids, like ?9-tetrahydrocannabinol (THC) and cannabidiol (CBD), activate/desensitize thermosensitive transient receptor potential (TRP) channels of vanilloid type-1 or -2 (TRPV1 or TRPV2). We investigated whether cannabinoids also activate/desensitize two other thermo-TRPs, the TRP channels of vanilloid type-3 or -4 (TRPV3 or TRPV4), and if the TRPV-inactive cannabichromene (CBC) modifies the expression of TRPV14 channels in the gastrointestinal tract.
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