Wnt signalling in murine postnatal mammary gland development

The mammary gland undergoes numerous developmental processes postnatally, from the elongation of the ductal tree-like structure to pregnancy-induced lobulo-alveolar development. Mammary epithelial stem cells have been suggested to be central to the control of enormous tissue expansion and remodelling during phases of mammary development. The Wnt signalling pathway plays a critical role in these biological steps and is suggested to be involved in the maintenance of the stem cell population. This review provides insight into recent findings on the activity of Wnt signalling during ductal and lobular mammary development and discusses the potential interplay between Wnt signals and mammary stem cells in mice.