Journal
ACTA PHYSIOLOGICA
Volume 199, Issue 2, Pages 221-230Publisher
WILEY
DOI: 10.1111/j.1748-1716.2010.02091.x
Keywords
body weight; diurnal; heat production; knock-out; sex differences
Categories
Funding
- Swedish Science Research Council [2553]
- Heart and Lung fund
- NIH [Ro1 NS048995]
- Novo Nordisk Fund for Endocrinological Research, Hjarnfonden
- Knut and Alice Wallenberg Foundation [2005.0120]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS048995] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Aim: To examine the phenotype of mice that lack the adenosine A(3) receptor (A(3)R). Methods: We examined the heart rate, body temperature and locomotion continuously by telemetry over several days. In addition, the effect of the adenosine analogue R-N6-phenylisopropyl-adenosine (R-PIA) was examined. We also examined heat production and food intake. Results: We found that the marked diurnal variation in activity, heart rate and body temperature, with markedly higher values at night than during day time, was reduced in the A(3)R knock-out mice. Surprisingly, the reduction in heart rate, activity and body temperature seen after injection of R-PIA in wild type mice was virtually eliminated in the A(3)R knock-out mice. The marked reduction in activity was associated with a decreased heat production, as expected. However, the A(3)R knock-out mice, surprisingly, had a higher food intake but no difference in body weight compared to wild type mice. Conclusions: The mice lacking adenosine A(3) receptors exhibit a surprisingly clear phenotype with changes in diurnal rhythm and temperature regulation. Whether these effects are due to a physiological role of A(3) receptors in these processes or whether they represent a role in development remains to be elucidated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available