Journal
NATURE REVIEWS CANCER
Volume 10, Issue 6, Pages 425-434Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2843
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Funding
- Cancer Council of Victoria
- National Institutes of Health, Bethesda [CA22556]
- National Health and Medical Research Council, Canberra [461219]
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The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.
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