Journal
PHARMACEUTICALS
Volume 3, Issue 6, Pages 1873-1886Publisher
MDPI
DOI: 10.3390/ph3061873
Keywords
pathogens; virus infection; immunomodulation; inflammation
Categories
Funding
- U.S. National Institutes of Health [DC039746, NS039746]
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Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections.
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