Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 309, Issue 10, Pages L1076-L1087Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajplung.00286.2015
Keywords
noncoding ribonucleic acid; immunity; asthma; chronic obstructive pulmonary disease; cystic fibrosis; acute respiratory distress syndrome
Categories
Funding
- National Heart, Lung, and Blood Institute [HL-114470, HL-105473, HL-076206]
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Despite the greatly expanded knowledge on the regulation of immune response by protein molecules, there is increasing understanding that noncoding RNAs (ncRNAs) are also an integral component of this regulatory network. Abnormal immune response serves a central role in the initiation, progression, and exacerbation of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and acute respiratory distress syndrome/acute lung injury. Dysregulation of ncRNAs has been linked to various immunopathologies. In this review, we highlighted the role of ncRNAs in the regulation of innate and adaptive immunity and summarized recent findings that ncRNAs participate in the pathogenesis of inflammatory lung diseases via their regulation of pulmonary immunity. We also discussed therapeutic potentials for targeting ncRNAs to treat these lung disorders.
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