Journal
ACTA PHARMACOLOGICA SINICA
Volume 33, Issue 10, Pages 1217-1245Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2012.90
Keywords
natural products; phytochemistry; protein tyrosine phosphatase 1B (PTP1B); inhibitor; structure-activity relationship (SAR); type 2 diabetes; obesity
Funding
- National Marine 863 Project [2011AA09070102]
- Natural Science Foundation of China [31070310, 40976048, 21021063, 21072204, 81072572]
- SKLDR/SIMM Projects [SIMM1203ZZ-03, SIMM1105KF-04]
- National S&T Major Projects [2011ZX09307-002-03]
- EU 7th Framework Programme-IRSES Project
Ask authors/readers for more resources
This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
