Journal
ACTA PHARMACOLOGICA SINICA
Volume 33, Issue 9, Pages 1147-1158Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/aps.2012.105
Keywords
natural products; plant resources; traditional Chinese medicine; bioactive compounds; structural modification; structure-activity relationship
Funding
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program [2011ZX09307-002-03]
- foundation of the Ministry of Science and Technology of China [2012CB721105]
- National Natural Science Foundation of China [30025044, 30630072, 21072203]
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This review describes the major discoveries of structurally diverse and/or biologically significant compounds from plant resources in China, mainly from the traditional Chinese medicines (TCMs) since the establishment of our research group in 1999. In the past decade, a large array of biologically significant and novel structures has been identified from plant resources (or TCM) in our laboratory. The structural modification of several biologically important compounds led to more than 400 derivatives, some of which exhibited significantly improved activities and provided opportunities to elucidate the structure-activity relationship of the related compound class. These findings are important for drug discovery and help us understand the biological basis for the traditional applications of these plants in TCM.
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