Related references
Note: Only part of the references are listed.The worldwide societal costs of dementia: Estimates for 2009
Anders Wimo et al.
ALZHEIMERS & DEMENTIA (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
Cynthia A. Lemere et al.
NATURE REVIEWS NEUROLOGY (2010)
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
Bart De Strooper
PHYSIOLOGICAL REVIEWS (2010)
Amyloid Deposition and Inflammation in APPswe/PS1dE9 Mouse Model of Alzheimer's Disease
Lingfei Ruan et al.
CURRENT ALZHEIMER RESEARCH (2009)
Amino Acid Position-specific Contributions to Amyloid β-Protein Oligomerization
Samir K. Maji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Meta-basic estimates the size of druggable human genome
Dariusz Plewczynski et al.
JOURNAL OF MOLECULAR MODELING (2009)
β-Amyloid Monomers Are Neuroprotective
Maria Laura Giuffrida et al.
JOURNAL OF NEUROSCIENCE (2009)
Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses
Efrat Abramov et al.
NATURE NEUROSCIENCE (2009)
Small Molecule Protein-Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles
Levi L. Blazer et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors
Antero Salminen et al.
PROGRESS IN NEUROBIOLOGY (2009)
Soluble amyloid-β peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo
Neng-Wei Hu et al.
BRAIN (2008)
Principles of protein-protein interactions: What are the preferred ways for proteins to interact?
Ozlem Keskin et al.
CHEMICAL REVIEWS (2008)
Role of the region 23-28 in Aβ fibril formation:: Insights from simulations of the monomers and dimers of Alzheimer's peptides Aβ40 and Aβ42
Adrien Melquiond et al.
CURRENT ALZHEIMER RESEARCH (2008)
Why is the amyloid beta peptide of Alzheimer's disease neurotoxic?
Arvi Rauk
DALTON TRANSACTIONS (2008)
Structure and dynamics of the Aß21-30 peptide from the interplay of NMR experiments and molecular simulations
Nicolas L. Fawzi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Mixed results for disease-modification strategies for Alzheimer's disease
Alisa Opar
NATURE REVIEWS DRUG DISCOVERY (2008)
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ
Paul A. Adlard et al.
NEURON (2008)
Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
R. Resende et al.
NEUROSCIENCE (2008)
C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity
Erica A. Fradinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation
Wolfgang Hoyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Amyloid fibrils of the HET-s(218-289) prion form a β solenoid with a triangular hydrophobic core
Christian Wasmer et al.
SCIENCE (2008)
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
P. Hemachandra Reddy et al.
TRENDS IN MOLECULAR MEDICINE (2008)
At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism
Taisuke Tomita
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid
Sandra Chimon et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Insight into the kinetic of amyloid β(1-42) peptide self-aggregation:: Elucidation of inhibitors' mechanism of action
Manuela Bartolini et al.
CHEMBIOCHEM (2007)
Synaptic memory mechanisms:: Alzheimer's disease amyloid β-peptide-induced dysfunction
M. J. Rowan et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Molecular basis for passive immunotherapy of Alzheimer's disease
Anna S. Gardberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: Influence of linker length and flexibility
Ashley A. Reinke et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2007)
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity
Jijun Dong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure and dynamics of parallel β-sheets, hydrophobic core, and loops in Alzheimer's Aβ fibrils
Nicolae-Viorel Buchete et al.
BIOPHYSICAL JOURNAL (2007)
β-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange
Xiaojun Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure-based maximal affinity model predicts small-molecule druggability
Alan C. Cheng et al.
NATURE BIOTECHNOLOGY (2007)
Disrupting beta-amyloid aggregation for Alzheimer disease treatment
L. D. Estrada et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice
Kouhei Nishitomi et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Binding of amyloid β-peptide to ganglioside micelles is dependent on histidine-13
Mike P. Williamson et al.
BIOCHEMICAL JOURNAL (2006)
Interrogating the druggable genome with structural informatics
Kevin Hambly et al.
MOLECULAR DIVERSITY (2006)
Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
JoAnne McLaurin et al.
NATURE MEDICINE (2006)
Exploring protein-ligand recognition with binding MOAD
RD Smith et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2006)
On the nucleation of amyloid β-protein monomer folding
ND Lazo et al.
PROTEIN SCIENCE (2005)
Formation and stabilization model of the 42-mer Aβ radical:: Implications for the long-lasting oxidative stress in Alzheimer's disease
K Murakami et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es et al.
NATURE (2005)
Aβ40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid
KL Sciarretta et al.
BIOCHEMISTRY (2005)
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
MR Arkin et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Deciphering the molecular basis of memory failure in Alzheimer's disease
DM Walsh et al.
NEURON (2004)
Strategies for disease modification in Alzheimer's disease
M Citron
NATURE REVIEWS NEUROSCIENCE (2004)
In silico study of amyloid β-protein folding and oligomerization
B Urbanc et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Processing of Notch and amyloid precursor protein by γ-secretase is spatially distinct
L Tarassishin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Harnessing chaperones to generate small-molecule inhibitors of amyloid β aggregation
JE Gestwicki et al.
SCIENCE (2004)
Alzheimer disease in the US population - Prevalence estimates using the 2000 census
LE Hebert et al.
ARCHIVES OF NEUROLOGY (2003)
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
LB Yang et al.
NATURE MEDICINE (2003)
Integration of NMR and high-throughput screening
PJ Hajduk et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2002)
A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro
Y Nakagami et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4-10 and inhibit cytotoxicity and fibrillogenesis
J McLaurin et al.
NATURE MEDICINE (2002)
Principles of protein-protein interactions
SA Teichmann
BIOINFORMATICS (2002)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
MA Leissring et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
YH Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
S Kitazume et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
Y Luo et al.
NATURE NEUROSCIENCE (2001)
A beta-generating enzymes: Recent advances in beta- and gamma-secretase research
R Vassar et al.
NEURON (2000)