Journal
ACTA PHARMACEUTICA
Volume 60, Issue 2, Pages 141-152Publisher
HRVATSKO FARMACEUTSKO DRUSTOV (HFD)-CROATION PHARMACEUTICAL SOC
DOI: 10.2478/v10007-010-0017-8
Keywords
losartan potassium; amlodipine besilate; hydrochlorothiazide; spectrophotometry; chemometry
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Funding
- Adhiparasakthi Medical and Charitable Trust, Melmaruvathur
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In the present work, four different spectrophotometric methods for simultaneous estimation of losartan potassium, amlodipine besilate and hydrochlorothiazide in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, classical least squares (CLS), multiple linear regression (MLR), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix, with measurements in the range of 230.5-350.4 nm (Delta lambda - 0.1 nm) in their zero order spectra. The linearity range was found to be 8-40, 1-5 and 3-15 mu g mL(-1) for losartan potassium, amlodipine besilate and hydrochlorothiazide, respectively. The validity of the proposed methods was successfully assessed for analyses of drugs in the various prepared physical mixtures and in tablet formulations.
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