Journal
PHARMACEUTICALS
Volume 3, Issue 7, Pages 2146-2162Publisher
MDPI
DOI: 10.3390/ph3072146
Keywords
NSAIDs; aspirin; cardiovascular events
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While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs ( NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general black box warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.
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