Journal
ACTA PAEDIATRICA
Volume 103, Issue 6, Pages 578-585Publisher
WILEY
DOI: 10.1111/apa.12593
Keywords
Early nutrition; Growth; Infant nutrition; Metabolic programming; Obesity
Categories
Funding
- Commission of the European Communities, specific RTD Programme 'Quality of Life and Management of Living Resources', within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]
- 7th Framework Programme [FP7-289346-EARLY NUTRITION]
- European Research Council [322605 META-GROWTH]
- National Competence Network on Obesity [01 GI 0825]
- German Ministry of Education and Research, Berlin
- Child Health Foundation, Munich
- University of Munich Innovative Research Priority Project MC-Health (subproject I)
- 6th Framework Programme [007036]
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Infant nutrition has a major impact on immediate outcomes and long-term health and later disease risks, such as obesity and related disorders, a phenomenon referred to as metabolic programming'. This review discusses the currently postulated hypotheses and mechanisms investigated by the EarlyNutrition project. ConclusionRapid weight gain in the first 2years of life, most notably mediated by diary protein, affects the insulin-like growth factor metabolic pathways. Epigenetic processes seem to play a role.
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