Journal
ACTA PAEDIATRICA
Volume 102, Issue 10, Pages E439-E442Publisher
WILEY
DOI: 10.1111/apa.12339
Keywords
Growth-restricted; Inflammation; IUGR; Neonate; Preterm
Categories
Funding
- National Institute of Neurological Disorders and Stroke [5U01NS040069-05, 2R01NS040069 - 06A2]
- National Institute of Child Health and Human Development [5P30HD018655-28]
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Aim To compare the early post-natal pattern of systemic inflammation in growth-restricted infants born before the 28th week of gestation to that of appropriately grown peers. Methods We measured the concentrations of 25 inflammation-related proteins in blood spots collected from 939 newborns during the first 2 post-natal weeks. We calculated the odds ratios (99% confidence intervals) that concentrations would be in the highest quartile. Results Severely growth-restricted infants (birth weight Z-score <-2) were not at increased risk of systemic inflammation shortly after birth. On post-natal day 14, however, they were significantly more likely than their peers to have a CRP, IL-1, IL-6, TNF-, IL-8, MCP-4, ICAM-1, ICAM-3, E-SEL, MMP-9, VEGF-R2 and/or IGFBP-1 concentration in the highest quartile. These increased risks could not be attributed to delivery indication, bacteremia or duration of ventilation. Conclusion Growth-restricted preterm newborns appear to be at increased risk of elevated concentrations of inflammation-associated proteins by post-natal day 14.
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