Journal
ACTA PAEDIATRICA
Volume 101, Issue 8, Pages 819-826Publisher
WILEY
DOI: 10.1111/j.1651-2227.2012.02692.x
Keywords
Angiogenesis; Guidance cues; Neurons; Semaphorins; Succinate
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- Heart and Stroke Foundation of Canada
- Fonds de la Recherche en Sante du Quebec
- Le Reseau de Recherche en Sante de la Vision
- Canadian Stroke Network
Ask authors/readers for more resources
Retinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP. These hypoxia-generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A.Conclusion: Neuron-derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available