Journal
ACTA PAEDIATRICA
Volume 101, Issue 11, Pages 1128-1133Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1651-2227.2012.02797.x
Keywords
Preterm neonates; Screening; Transcutaneous bilirubin
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Aim: To investigate the trueness and uncertainty of two transcutaneous bilirubinometers BiliCheck and Minolta JM-103 in preterm infants; establish cut-off values for the transcutaneous bilirubin (TcB) level, indicating the need for total serum bilirubin (TsB) measurement; and estimate how many blood samples could be saved. Methods: In 133 neonates with gestational ages 28+034+6 weeks, 239 measurements of TcB by BiliCheck (TcB(B)) and JM-103 (TcB(M)) and of TsB were performed. Results: Median TsB of the first samples was 160 (range, 53293) mu mol/L, whereas median TcB(B) was 12 mu mol/L (8%) lower and TcB(M) 67 mu mol/L (40%) lower. TcB(B) underestimated TsB for TsB =180 mu mol/L. All TcB(M) values, except one, underestimated TsB. The underestimation increased with increasing TsB. Multiple regression analysis showed that post-natal age and ethnicity were confounding factors for TcB(M); none were found for TcB(B). The uncertainty was the same for the two instruments. By using cut-off values of 70% of the phototherapy limit for TcB(B) and 35% for TcB(M), the sensitivity of the screening would be 95% and 97%, and 36% and 24% of the blood samples could be saved, respectively. Conclusion: TcB determined with JM-103 gave values much lower than those obtained with BiliCheck. The underestimation of TsB increased with increasing concentrations. By using transcutaneous bilirubinometers in preterm neonates, 2436% of the blood samples could be saved.
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