Journal
ACTA OTO-LARYNGOLOGICA
Volume 132, Issue 2, Pages 141-145Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/00016489.2011.635383
Keywords
Endolymphatic hydrops; gadolinium; electrocochleogram
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Funding
- Ministry of Health, Labour and Welfare of Japan
- Acute Profound Deafness Research Committee of the Ministry of Health, Labour and Welfare of Japan
- Japanese Ministry of Health, Labour and Welfare
- Grants-in-Aid for Scientific Research [22890077, 23791887] Funding Source: KAKEN
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Conclusion. 3 T MRI after intratympanic injection of gadolinium-based contrast agent (GBCA) is more useful for the diagnosis of endolymphatic hydrops compared with the glycerol test and electrocochleography (ECoG). Objective: To investigate the relationship between 3 T MRI after intratympanic injection of GBCA, the glycerol test, and ECoG in patients with Meniere's disease (MD). Methods: A total of 20 patients with MD were evaluated. Diluted gadodiamide (a gadolinium-based contrast agent) was administered to the bilateral tympanic cavity by injection through the tympanic membrane. After 24 h, the endolymphatic hydrops was evaluated by a 3.0 T MR scanner. To investigate cochlear hydrops, the glycerol test and ECoG were carried out in all patients. Results: A positive result was observed in 11 patients (55%) in the glycerol test and in 12 patients (60%) by ECoG. The incidence of positive findings when evaluating the same patients with both the glycerol test and ECoG increased to 75%. Nineteen of 20 (95%) patients showed positive results for 3 T MRI.
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