Journal
ACTA OTO-LARYNGOLOGICA
Volume 131, Issue 5, Pages 474-479Publisher
INFORMA HEALTHCARE
DOI: 10.3109/00016489.2010.534114
Keywords
3 T magnetic resonance imaging; three-dimensional fluid attenuated inversion recovery; 3D FLAIR; contrast effect; signal intensity ratio; contralateral ear
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Funding
- Ministry of Health, Labour and Welfare
- Ministry of Education, Culture, Sports, Science and Technology in Japan
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Conclusions: The blood-labyrinth barrier is impaired in association with the hydrops grade in Meniere's disease. Objectives: To investigate the relationship between endolymphatic hydrops and the clinical characteristics of patients with Meniere's disease revealed by 3 T magnetic resonance imaging (MRI). Methods: A double dose of gadoteridol (Gd; 0.2 mmol/kg) was injected intravenously in 12 patients with Meniere's disease. We performed three-dimensional fluid attenuated inversion recovery MRI and three-dimensional real inversion recovery MRI 4 h later using a 3 T MRI unit. Ten patients had unilateral and two had bilateral Meniere's disease. Results: Fourteen ears with Meniere's disease showed intense Gd contrast on MRI compared with that in the 10 asymptomatic contralateral ears of patients with unilateral Meniere's disease (1.12 +/- 0.36 vs 0.82 +/- 0.15). The hydrops grade was correlated significantly with the contrast effect. The 14 ears with Meniere's disease had endolymphatic hydrops. Of the 10 contralateral ears of patients with unilateral Meniere's disease, 2 had endolymphatic hydrops in the cochlea and 6 had endolymphatic hydrops in the vestibule.
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