Functional diffusion map of malignant brain tumors: A surrogate imaging biomarker for early prediction of therapeutic response and patient survival

Purpose: To evaluate the ability of functional diffusion mapping fDM'' to early predict treatment response and survival in patients with primary malignant brain tumors. Patients and methods: Forty-six brain tumor patients were examined by diffusion MRI before and 3 weeks after initiation of chemo- and/or radiotherapy. Images were co-registered to pretherapy scans, and tumor volumes with significant changes in apparent diffusion coefficient values were spatially displayed as functional diffusion maps. The predictive values of percentage of change in whole-tumor volume, mean ADC and fDM parameters for treatment response were evaluated by their correlation with the standard clinico-radiologic response criteria and overall survival of the two response groups was determined. Results: Of the analyzed 46 brain tumors, 21 tumors were responding and 25 were stable/nonresponding. At 3 weeks after initiation of therapy, the percentage of tumor volume with significant increase in diffusion (VR; red voxels) was the strongest predictor of treatment response than the changes in whole-tumor volume and mean ADC values determined at the same time point as compared to their pretherapy values. VR threshold of 14.5% at 3 weeks had sensitivity, specificity, positive and negative predictive values of 100% for all for differentiating responding from stable/nonresponding tumors. Overall survival in stable/non-responding group was shorter than in the responding group (8.7 versus 35.6 months; **P < 0.001). Conclusion: The use of fDM provided an early and direct surrogate marker for predicting treatment response and patient survival in patients with malignant brain tumor. (C) 2010 Egyptian Society of Radiology and Nuclear Medicine. Production and hosting by Elsevier B.V. All rights reserved.