Hydroxychloroquine-induced acute psychosis in a systemic lupus erythematosus female

Background: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. Hydroxychloroquine, a kind of anti-malarial, has become an important treatment for SLE in recent years. Method: We want to report a 49 year-old female SLE patient, who had psychosis episode with hydroxychloroquine treatment. Result: There's still risk of psychosis with hydroxychloroquine treatment from the possible mechanism. Conclusion: Awareness of chloroquine-induced psychosis is very important, and psychiatric intervention is needed as soon as possible after this occurs.