Intrathecal levels of vitamin D and IgG in multiple sclerosis

Background -Intrathecal synthesis of IgG is a hallmark of multiple sclerosis (MS). Vitamin D may modulate B-cell function and dampen the synthesis of IgG. Objective -To investigate the relation between vitamin D levels in cerebrospinal fluid and serum and intrathecal synthesis of IgG. Methods -25-hydroxyvitamin D (25(OH) D) and IgG were assessed in cerebrospinal fluid and serum in 40 patients with MS. Results -There was no significant correlation between the IgG index and 25(OH) D levels in cerebrospinal fluid or serum. The levels of 25(OH) D in cerebrospinal fluid and serum did not differ between patients with and without intrathecal synthesis of IgG. There was a non-significant trend towards a positive correlation between the concentrations of 25(OH) D and IgG in the cerebrospinal fluid, but not in serum. Conclusion -Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in MS.