Journal
EMERGING INFECTIOUS DISEASES
Volume 16, Issue 10, Pages 1633-1636Publisher
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1610.100688
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- Tan Tock Seng Hospital
- Ministry of Health
- Agency for Science, Technology and Research, Singapore
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An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient's exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.
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