Journal
ACTA NEUROLOGICA SCANDINAVICA
Volume 120, Issue 6, Pages 439-441Publisher
WILEY
DOI: 10.1111/j.1600-0404.2009.01278.x
Keywords
apolipoprotein E; benign; disability; multiple sclerosis
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Background - No study has assessed the association between apolipoproteinE (APOE) and multiple sclerosis (MS) forms grouped by also taking into account cognitive performance. Aims of the study - To assess the relationship between APOE and disease course, particularly focusing on benign MS (BMS), defined as also including cognitive preservation. Methods - In 173 consecutive patients, we assessed the association between APOE and MS course and severity. Results - Twenty-nine APOE-epsilon 4 carriers were identified. The epsilon 4 allele was not associated with BMS. Moreover, it was associated neither with other disease courses nor with the time to reach disability milestones and secondary progression. Conclusion - Although plausible, the association between APOE and MS course (particularly with BMS defined by including cognitive preservation) and disease severity remains controversial.
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