Journal
ACTA NEUROLOGICA SCANDINAVICA
Volume 117, Issue -, Pages 72-76Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0404.2008.01036.x
Keywords
cuprizone; demyelination; multiple sclerosis
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Background - Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone. Materials and methods - This article reviews previous research on this model and discusses the potential of the model for future application in MS research. Discussion - The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de- and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.
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