Journal
NATURE REVIEWS CANCER
Volume 10, Issue 11, Pages 745-759Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2945
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Funding
- National Health and Medical Research Council of Australia
- Cancer Council of Victoria
- Victorian Breast Cancer Consortium, Australia
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For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion of vascular networks are required. There is accumulating molecular and in vivo evidence to indicate that the expression and actions of the renin angiotensin system (RAS) influence malignancy and also predict that RAS inhibitors, which are currently used to treat hypertension and cardiovascular disease, might augment cancer therapies. To appreciate this potential hegemony of the RAS in cancer, an expanded comprehension of the cellular actions of this system is needed, as well as a greater focus on translational and in vivo research.
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