Journal
INFLAMMATORY BOWEL DISEASES
Volume 21, Issue 8, Pages 1786-1793Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/MIB.0000000000000426
Keywords
enteral nutrition; pediatric Crohn's disease; anti-TNF; mucosal healing
Categories
Funding
- NIH [T32-DK007740, UH3-DK083981, K24-DK078228]
- Penn Digestive Disease Center [P30 DK050306]
- Joint Penn-CHOP Center for Digestive, Liver, and Pancreatic Medicine
- Penn-CHOP Microbiome Program
- Centocor
- Shire
- Takeda
- Nestec Ltd.
- Abbvie
- Janssen
- Astra Zeneca
- Optimer
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Background:Therapeutic targets in pediatric Crohn's disease include symptoms, quality of life (QOL), and mucosal healing. Although partial enteral nutrition (PEN), exclusive enteral nutritional (EEN), and anti-tumor necrosis factor alpha (anti-TNF) therapy all improve symptoms, the comparative effectiveness of these approaches to improve QOL and achieve mucosal healing has not been assessed prospectively.Methods:In a prospective study of children initiating PEN, EEN, or anti-TNF therapy for Crohn's disease, we compared clinical outcomes using the Pediatric Crohn's Disease Activity Index (PCDAI), QOL (IMPACT score), and mucosal healing as estimated by fecal calprotectin (FCP). PCDAI, IMPACT, FCP, and diet (prompted 24-h recall) were measured at baseline and after 8 weeks of therapy.Results:We enrolled 90 children with active Crohn's disease (PCDAI, 33.7 13.7; and FCP, 976 +/- 754), of whom 52 were treated with anti-TNF, 22 with EEN, and 16 with PEN plus ad lib diet. Clinical response (PCDAI reduction 15 or final PCDAI 10) was achieved by 64% on PEN, 88% EEN, and 84% anti-TNF (test for trend P = 0.08). FCP 250 g/g was achieved with PEN in 14%, EEN 45%, and anti-TNF 62% (test for trend P = 0.001). Improvement in overall QOL was not statistically significantly different between the 3 groups (P = 0.86). However, QOL improvement was the greatest with EEN in the body image (P = 0.03) domain and with anti-TNF in the emotional domain (P = 0.04).Conclusions:Although PEN improved clinical symptoms, EEN and anti-TNF were more effective for decreasing mucosal inflammation and improving specific aspects of QOL.
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