Journal
FEMS MICROBIOLOGY REVIEWS
Volume 34, Issue 6, Pages 925-951Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2010.00217.x
Keywords
arsenic; cadmium; chromium; selenium; metal toxicity; metal detoxification
Categories
Funding
- Swedish Research Council
- Swedish Research Links programme
- Polish Ministry of Science and Higher Education
Ask authors/readers for more resources
Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance. This review provides an overview of the molecular mechanisms that contribute to metal toxicity, detoxification and tolerance acquisition in budding yeast Saccharomyces cerevisiae. We mainly focus on the metals/metalloids arsenic, cadmium, antimony, mercury, chromium and selenium, and emphasize recent findings on sensing and signalling mechanisms and on the regulation of tolerance and detoxification systems that safeguard cellular and genetic integrity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available