Journal
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
Volume 29, Issue 2, Pages 295-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2015.02.005
Keywords
Lyme disease; Borrelia burgdorferi; Laboratory diagnosis; Serology
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Funding
- Intramural Research Program National Institute of Allergy and Infectious Diseases, NIH
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The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field.
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