Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography

PURPOSE. To evaluate the strength and pattern of the relationship between visual field (VF) mean sensitivity (MS), assessed by standard automated perimetry (SAP), and macular ganglion cell complex thickness (GCCT), measured with spectral-domain optical coherence tomography (SD-OCT). METHODS. Ninety-seven glaucoma patients were enrolled. GCCT, determined by ganglion cell complex (GCC) scanning, and two peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements, using the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes, were recorded. MS was recorded on the decibel (dB) and 1/L scales. The relationship between function (MS) and structure (GCC, pRNFLT) was sought. RESULTS. The association of MS (in decibels) with GCC global (r = 0.445) and sectoral (superior, r = 0.528; inferior, r = 0.370) thicknesses was not significantly different from that of MS to global (RNFL1, r = 0.505; RNFL2, r = 0.498) and sectoral (RNFL 1 superior, r = 0.559; inferior, r = 0.440; RNFL 2 superior, r = 0.535; inferior, r = 0.443) pRNFLT, on linear regression analysis. The relationship pattern was curvilinear on the dB scale against GCCT and RNFLT. Logarithmic regression of MS (using both the dB and 1/L scales) against GCCT and RNFLT was better than linear regression in describing the pattern of association. CONCLUSIONS. GCCT, determined by SD-OCT, showed correlation to MS of a strength similar to that demonstrated between MS and pRNFLT. (Invest Ophthalmol Vis Sci. 2010;51:6401-6407) DOI:10.1167/iovs.09-5035