Journal
INFECTION GENETICS AND EVOLUTION
Volume 33, Issue -, Pages 95-100Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2015.04.016
Keywords
Clade 2.3.4; Highly pathogenic avian influenza; H5N1
Categories
Funding
- Science and Technology Program from Yunnan Province [2012CH002]
- Key Program of the National Public Welfare Industry [201103008]
- Science and Technology Programs of Military [CWS12J075, 13BJYZ37, A12005, BWS14J025]
- Youth Fund Program from National Natural Science Foundation of China [81101618]
- [AWS11L009]
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From December 2013 to March 2014, a major wave of highly pathogenic avian influenza outbreak occurred in poultry in Yunnan Province, China. We isolated and characterized eight highly pathogenic avian influenza A (H5N1) viruses from poultry. Full genome influenza sequences and analyses have been performed. Sequence analyses revealed that they belonged to clade 2.3.4 but did not fit within the three defined subclades. The isolated viruses were provisional subclade 2.3.4.4e. The provisional subclade 2.3.4.4e viruses with six internal genes from avian influenza A (H5N2) viruses in 2013 were the novel reassortant influenza A (H5N1) viruses which were associated with the outbreak of H5N1 occurred in egg chicken farms in Yunnan Province. The HA genes were similar to subtype H5 viruses isolated from January to March of 2014 in Asia including H5N6 and H5N8. The NA genes were most closely related to A/chicken/Vietnam/NCVD-KA423/2013 (H5N1) from the subclade 2.3.2. The HI assay demonstrated a lack of antigenic relatedness between clades 2.3.4.4e and 2.3.4.1 (RE-5 vaccine strain) or 2.3.2.2 (RE-6 vaccine strain). (C) 2015 Elsevier B.V. All rights reserved.
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