Journal
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
Volume 36, Issue 8, Pages 942-948Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/ice.2015.118
Keywords
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Funding
- National Institute Of Allergy And Infectious Diseases of the National Institutes of Health [UM1AI104681]
- Clinical and Translational Science Collaborative of Cleveland from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health [UL1TR000439]
- NIH roadmap for Medical Research
- Mid-Career Mentoring Award from NIH [K24-AI093969]
- Veterans Affairs Merit Review Program
- National Institutes of Health [AI072219-05, AI063517-07]
- Geriatric Research Education and Clinical Center VISN [10]
- Research Program Committees of the Cleveland Clinic
- STERIS Corporation
- National Institute of Allergy and Infectious Diseases (DMID) [protocol 10-0065]
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OBJECTIVE. To determine the rates of and risk factors for tigecycline nonsusceptibility among carbapenem-resistant Klebsiella pneumoniae (CRKPs) isolated from hospitalized patients DESIGN. Multicenter prospective observational study SETTING. Acute care hospitals participating in the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRaCKle) PATIENTS. A cohort of 287 patients who had CRICPs isolated from clinical cultures during hospitalization METHODS. For the period from December 24, 2011 to October 1, 2013, the first hospitalization of each patient with a CRKP during which tigecycline susceptibility for the CRKP isolate was determined was included. Clinical data were entered into a centralized database, including data regarding pre-hospital origin. Breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) were used to interpret tigecycline susceptibility testing. RESULTS. Of 287 patients included in the final cohort, 155 (54%) had tigecycline-susceptible CRKPs. Of all index isolates, 81(28%) were tigecycline-intermediate and 51 (18%) were tigecycline resistant. In multivariate modeling, independent risk factors for tigecycline nonsusceptibility were (1) admission from a skilled nursing facility (OR, 2.51; 95% CI, 1.51-4.21; P=.0004), (2) positive culture within 2 days of admission (OR, 1.82; 95% CI, 1.06-3.15; P=.03), and (3) receipt of tigecycline within 14 days (OR, 4.38, 95% CI, 1.37-17.01, P=.02). CONCLUSIONS. In hospitalized patients with CRKPs, tigecydine nonsusceptibility was more frequently observed in those admitted from skilled nursing facilities and occurred earlier during hospitalization. Skilled nursing facilities are an important target for interventions to decrease antibacterial resistance to antibiotics of last resort for treatment of CRKPs.
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