Journal
CURRENT FUNGAL INFECTION REPORTS
Volume 4, Issue 4, Pages 266-275Publisher
SPRINGER
DOI: 10.1007/s12281-010-0035-5
Keywords
Fungi; Biofilms; Antifungal drugs; Immune response; Gene expression; Quorum sensing; Therapy
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Funding
- NIAID NIH HHS [R01 AI059681, R01 AI059681-05] Funding Source: Medline
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The use of indwelling medical devices is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms. Fungal biofilms have emerged as a clinical problem associated with these medical device infections, causing significant morbidity and mortality. This review discusses the recent advances in the understanding of fungal biofilms, including the role of fungal surface components in adherence, gene expression, and quorum sensing in biofilm formation. We propose novel strategies for the prevention or eradication of microbial colonization of medical prosthetic devices.
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