Journal
INFECTION AND IMMUNITY
Volume 83, Issue 11, Pages 4373-4382Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00466-15
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Funding
- Campbell Laboratory of Ophthalmic Microbiology
- Eye and Ear Foundation of Pittsburgh
- Research to Prevent Blindness
- NIH [AI085570]
- NEI Core Grant for Vision Research [EY08098]
- NIH training grant [2T32 EY017271]
- [P30CA047904]
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Serratia marcescens is a soil-and water-derived bacterium that secretes several host-directed factors and causes hospital infections and community-acquired ocular infections. The putative two-component regulatory system composed of EepR and EepS regulates hemolysis and swarming motility through transcriptional control of the swrW gene and pigment production through control of the pigA-pigN operon. Here, we identify and characterize a role for EepR in regulation of exoenzyme production, stress survival, cytotoxicity to human epithelial cells, and virulence. Genetic analysis supports the model that EepR is in a common pathway with the widely conserved cyclic-AMP receptor protein that regulates protease production. Together, these data introduce a novel regulator of host-pathogen interactions and secreted-protein production.
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