Journal
ACTA MATERIALIA
Volume 61, Issue 3, Pages 912-930Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.actamat.2012.10.046
Keywords
Self-assembly; Biomaterials; Peptides; Peptide amphiphiles; Regenerative medicine
Funding
- National Institutes of Health [5R01DE015920-07, 5R01EB003806-07]
- US Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-FG02-00ER45810]
- National Science Foundation [DMR1006713]
- IIN Postdoctoral Fellowship
- Northwestern International Institute for Nanotechnology
- NIH Ruth L. Kirschstein NRSA postdoctoral fellowship [1F32NS077728-01A1]
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The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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