Journal
ANATOMY & CELL BIOLOGY
Volume 43, Issue 4, Pages 269-279Publisher
MEDRANG
DOI: 10.5115/acb.2010.43.4.269
Keywords
Neuronal migration; Rostral migratory stream; Neuroblasts; Adult neurogenesis
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Funding
- Korean Ministry of Education, Science and Technology via Brain Research Center of the 21st century Frontier Program in Neuroscience [2010K000803]
- National Research Foundation of Korea [20100020237]
- National Research Foundation of Korea [2008-0057782] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.
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