Journal
NATURE REVIEWS IMMUNOLOGY
Volume 10, Issue 12, Pages 813-825Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2886
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Funding
- US National Institutes of Health [R01 DK074500, P01 AI045757]
- American Association for Cancer Research
- National Health Medical Research Council
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T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.
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