Journal
CURRENT FUNGAL INFECTION REPORTS
Volume 4, Issue 4, Pages 238-243Publisher
SPRINGER
DOI: 10.1007/s12281-010-0034-6
Keywords
T helper cells; Gamma delta T cells; Cytotoxic T cells; Regulatory T cells; Th1; Th17; Th2; Fungal infection; Candida; Aspergillus; Histoplasma; Pneumocystis; Cryptococcus; IL-17; Interferon gamma; IL-4; IL-10; Plasticity; Interaction; Adaptive immunity; Cytokine responses
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Funding
- Netherlands Foundation for Scientific Research
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It has been long appreciated that protective immunity against fungal pathogens is dependent on activation of cellular adaptive immune responses represented by T lymphocytes. The T-helper (Th) 1/Th2 paradigm has proven to be essential for the understanding of protective adaptive host responses. Studies that have examined the significance of regulatory T cells in fungal infection, and the recent discovery of a new T-helper subset called Th17 have provided crucial information for understanding the complementary roles played by the various T-helper lymphocytes in systemic versus mucosal antifungal host defense. This review provides an overview of the role of the various T-cell subsets during fungal infections and the reciprocal regulation between the T-cell subsets contributing to the tailored host response against fungal pathogens.
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