4.5 Article

Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes

Journal

ACTA DIABETOLOGICA
Volume 51, Issue 5, Pages 739-748

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s00592-014-0581-3

Keywords

Pancreatic volume; Pancreatic fat; Type 2 diabetes; Multidetector-row computed tomography

Funding

  1. Korean Health Technology Research and Development project, Ministry of Health and Welfare, Republic of Korea [A090623, A092077]
  2. Seoul National University Bundang Hospital Research Fund [03-2009-003]
  3. Korea Health Promotion Institute [A090623] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Pancreatic volume and fat content might be associated with beta-cell function or insulin resistance (IR). We investigated the difference in pancreatic volume and fat content between age- and body mass index (BMI)-matched normal subjects and patients with having different durations of type 2 diabetes (T2D). We compared pancreatic volume and fat parameters between 50 age- and BMI-matched normal subjects, 51 subjects with newly diagnosed type 2 diabetes (T2D-new), 53 subjects with T2D < 5 years (T2D < 5Y), and 52 subjects with T2D a parts per thousand yen5 years (T2Da parts per thousand yen5Y). Age and BMI were matched to range of +/- 2 years and +/- 0.5 kg/m(2), respectively. Pancreatic volume and fat were measured by multidetector-row computed tomography with 64 detector-row scanner. The difference in Hounsfield units between pancreas and spleen (HUp-s) was investigated for fat density. Anthropometric and biochemical parameters including the homeostasis model assessment of IR (HOMA-IR) and the insulinogenic index (IGI) were measured. Compared with normal subjects, patients with T2D had significantly smaller pancreatic volume, greater pancreatic fat, and lower HUp-s. Among the groups with T2D, pancreatic volume decreased and pancreatic fat percentage and HUp-s increased from the T2D-new to the T2D < 5Y and T2D > 5Y groups. Pancreatic volume and fat and HUp-s values were associated with HbA1c and triglyceride levels. Pancreatic volume was correlated with IGI while pancreatic fat and HUp-s values were correlated with HOMA-IR. The current study suggests that pancreatic volume and fat deposition might be associated with the development and progression of T2D in Korean subjects.

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