Journal
ACTA DIABETOLOGICA
Volume 47, Issue 2, Pages 119-124Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s00592-009-0127-2
Keywords
VEGF; Diabetes mellitus type 2; Endothelial dysfunction
Categories
Funding
- VEGA [1/2309/05, 1/3381/06]
- Comenius University [77/2007, 421/2008]
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Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immunosorbent assay in all subjects. VEGF was significantly higher in NAU compared to controls. The difference between MAU and controls was not statistically significant, but there was a trend toward significance. Only TAFI correlated with VEGF in MAU. An observed significant increase of serum VEGF level already in NAU suggests that serum VEGF could be a sensitive predictor of endothelial dysfunction in type 2 diabetes.
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