Journal
ACTA DERMATO-VENEREOLOGICA
Volume 99, Issue 2, Pages 139-145Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-3050
Keywords
nbUVB phototherapy; atopic dermatitis; 25-hydroxy-vitamin D; regulatory T cells; filaggrin
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Funding
- Capital Region of Denmark Foundation for Health Research
- Aage Bang Foundation
- University of Copenhagen
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This study investigated serum 25-hydroxyvitamin D (25(OH) D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH) D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48-43.52, p < 0.0001, n = 25; and from baseline to week 4: 50.30 nmol/l, CI 37.28-63.33, p < 0.0001, n = 18). This increase was independent of the filaggrin gene loss-of-function mutation status. Flow cytometry showed no significant change in regulatory T cells or cytokine profiles of T cells in blood. Real-time quantitative PCR showed no change in skin cytokine levels. In conclusion, nbUVB phototherapy was associated with increased serum 25(OH) D concentrations, but not changes in circulating regulatory T cells in patients with atopic dermatitis.
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