Journal
ACTA DERMATO-VENEREOLOGICA
Volume 94, Issue 6, Pages 640-644Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-1815
Keywords
alkaline agents; atopic dermatitis; filaggrin mutations; natural moisturising factor; transepidermal water loss; irritant contact dermatitis
Categories
Funding
- COST Action (Skin Barrier in Atopic Diseases, SKINBAD) [BM0903]
Ask authors/readers for more resources
Dermal exposure to alkaline agents may lead to skin barrier damage and irritant contact dermatitis. The objective of this study was to investigate the effects of cumulative exposure to 0.5% sodium lauryl sulphate (SLS) and 0.15% NaOH on the barrier function and natural moisturising factor (NMF) levels in atopic dermatitis and healthy volunteers with known filaggrin genotype. The skin response was monitored by measurement of erythema and transepidermal water loss. The stratum corneum NMF levels were determined by high-performance liquid chromatography. Repeated exposure to 0.5% SLS and/or 0.15% NaOH in atopic dermatitis resulted in more severe impairment of the skin barrier function. Cumulative exposure to the irritants reduced significantly NMF in both the atopic and healthy controls group. The pronounced decrease of NMF after repeated single and sequential irritant exposure may be a patho-genetically relevant factor for development of chronic irritant contact dermatitis in both healthy and atopic individuals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available