Journal
ACTA DERMATO-VENEREOLOGICA
Volume 89, Issue 1, Pages 28-32Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/00015555-0541
Keywords
prospective survey; atopic dermatitis; allergic rhinitis; asthma
Categories
Funding
- Edvard Welander
- Finsen
- Vardal Foundations
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The active metabolite of vitamin D, 1,25-(OH)(2)D(3), has immunomodulatory properties in addition to its more established action on bone and calcium metabolism. Recently vitamin D has been proposed as one of several environmental factors responsible for the increase in atopic diseases during the last decades. The objective of this study was to determine whether the estimated dose of dietary vitamin D(3) during the first year of life is associated with atopic diseases up to the age of 6 years. In a prospective birth cohort study 123 six-year-old children were investigated for the cumulative incidence of atopic dermatitis, allergic rhinitis or asthma by means of a postal questionnaire. Their vitamin D(3) intake during infancy was recorded in a previous study and the relationship between lower or higher vitamin D(3) intake and atopic illness later in childhood was assessed. Atopic manifestations were more prevalent in the group with higher intake of vitamin D(3). Although small, this study supports previous investigations suggesting a role of vitamin D intake during infancy in the development of atopic allergy later in childhood. If these findings are confirmed in prospective controlled clinical trials, prevention through modified vitamin D(3) supplementation in infancy could be discussed to reduce the burden of atopic illnesses.
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