Journal
ACTA CYTOLOGICA
Volume 58, Issue 1, Pages 103-107Publisher
KARGER
DOI: 10.1159/000355861
Keywords
Breast implant; Anaplastic large-cell lymphoma; Total capsulectomy; Anaplastic large-cell kinase
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Background: Primary anaplastic large-cell lymphoma (ALCL) occurring in women with breast implants is very rare. It is usually described as tumor cells infiltrating the periprosthet-ic capsule. These are most often revealed by a periprosthetic recurrent isolated effusion (seroma cavity), occurring late after implantation of the prosthesis. ALCL is more rarely a tumor or periprosthetic capsular contracture. Case: We report a 66-year-old woman, initially diagnosed by cytological examination of breast effusion, in whom ALCL appeared two and a half months after the removal of a ruptured implant. Repeated biopsies of the periprosthetic capsule performed in parallel showed fibrous tissue, without tumor prolifera-tion. Only meticulous histological examination of the total capsulectomy identified tumor cells as a thin and discontinuous layer along the inner surface of the capsule without capsular invasion. Conclusion: Awareness of the histological pattern of this new clinical entity is important. A total capsulectomy with a good sampling for microscopic examination should be conducted for any suspicion of breast implantassociated ALCL. Cytology-histology correlation is essential. (C) 2013 S. Karger AG, Basel
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