Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 2, Pages 143-154Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2937
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Funding
- Danish Medical Research Council [09-072,636]
- Lundbeck Foundation [R34-A3855]
- US National Institutes of Health [AI067497, AI64349, AI083713, AI079293]
- Science Foundation Ireland
- Velux Fonden, Kathrine og Vigo Skovgaards Fond and Elvira og Rasmus Riisforts almenvelgorende Fond
- Lundbeck Foundation [R34-2009-3855] Funding Source: researchfish
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Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.
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