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Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii

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INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S1744309113014036

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  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [24109017]
  2. Japan Society for the Promotion of Sciences [21510237]
  3. Academia Sinica
  4. National Synchrotron Radiation Research Center (Taiwan)
  5. Grants-in-Aid for Scientific Research [21510237, 24109017] Funding Source: KAKEN

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The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 angstrom. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx).

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